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Saquinavir capsules

What is this medicine?

SAQUINAVIR (sa KWIN a veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take this medicine with ritonavir at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • fast, irregular heartbeat

  • feeling faint or lightheaded, falls

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • increased hunger or thirst

  • increased urination

  • nausea, vomiting

  • stomach pain

  • weight gain around waist, back, or thinning of face, arms, legs

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alfuzosin

  • atazanavir

  • certain medicines for cholesterol like lovastatin, red yeast rice, simvastatin

  • chloroquine

  • cisapride

  • clarithromycin

  • clozapine

  • cobicistat

  • dasatinib

  • droperidol

  • erythromycin

  • garlic supplements

  • haloperidol

  • lurasidone

  • medicines for headaches like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • medicines for irregular heart beat like amiodarone, bepridil, disopyramide, dofetilide, flecainide, ibutilide, lidocaine, propafenone, quinidine

  • methadone

  • midazolam

  • naloxegol

  • pentamidine

  • phenothiazines like chlorpromazine, fluphenazine, perphenazine, prochlorperazine, thioridazine, trifluoperazine

  • pimozide

  • quinine

  • ranolazine

  • rifampin

  • rilpivirine

  • sertindole

  • sildenafil

  • St. John's wort

  • sunitinib

  • tacrolimus

  • trazodone

  • triazolam

  • ziprasidone

This medicine may also interact with the following medications:

  • alfentanil

  • atorvastatin

  • arsenic trioxide

  • bosentan

  • certain medicines for blood pressure, heart disease, irregular heart beat like amlodipine, digoxin, diltiazem, felodipine, ibutilide, isradipine, nifedipine, nicardipine, nimodipine, nisoldipine, procainamide, sotalol, verapamil

  • colchicine

  • cyclosporine

  • corticosteroids like betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, prednisone, triamcinolone

  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections

  • fentanyl

  • medicines for depression, anxiety, or psychotic disturbances like alprazolam, amitriptyline, clomipramine, clorazepate, diazepam, flurazepam, imipramine, maprotiline, nefazodone, quetiapine

  • medicines for diabetesmedicines for erectile dysfunction like tadalafil and vardenafil

  • medicines for infections like dapsone, fusidic acid, ketoconazole, itraconazole, quinupristin; dalfopristin, rifabutin, rifapentine

  • medicines for seizures like carbamazepine, phenobarbital, phenytoin

  • medicines for stomach problems like esomeprazole, omeprazole, pantoprazole, rabeprazole, ranitidine

  • other medicines for HIV like delavirdine, efavirenz, maraviroc, nelfinavir, nevirapine, indinavir, lopinavir; ritonavir, tipranavir

  • sirolimus

  • vincamine

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store tightly closed at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes

  • heart disease

  • hemophilia

  • history of irregular heartbeat

  • history of low levels of calcium, magnesium, or potassium in the blood

  • liver disease

  • an unusual or allergic reaction to saquinavir, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier
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